Laboratory testing for <scp>ADAMTS13</scp> : Utility for <scp>TTP</scp> diagnosis/exclusion and beyond

The metalloproteinase ADAMTS13 (a disintegrin with a thrombospondin type 1 motif, member 13), also known as VWF (von Willebrand factor) protease, may be assessed in vast array of clinical conditions. Notably, severe deficiency characterizes TTP (thrombotic thrombocytopenic purpura), rare but potentially fatal disorder associated thrombosis due to accumulation prothrombotic ultra-large multimers. Although prompt identification/exclusion can facilitated by rapid testing, the most commonly utilized assays are based on ELISA (enzyme linked immunosorbent assay) and require long turnaround time have relatively limited throughput. Nevertheless, several now available, at least select geographies. current mini-review discusses these issues, well potential utility testing range other conditions, including coronavirus disease 2019 (COVID-19).